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Saturday, April 13 2024

Replace newborn calf serum with animal-free method for COVAXIN Production: PETA

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New Delhi: In a letter sent this morning, People for the Ethical Treatment of Animals (PETA) India requested that the Drugs Controller General of India, Dr VG Somani, direct vaccine manufacturers to replace newborn calf serum (NBCS) with animal-free, commercially available, and chemically defined media in the production of the COVID-19 vaccine. The recommendation comes in light of a report that COVAXIN – a COVID-19 vaccine indigenously developed by Bharat Biotech in collaboration with the Indian Council of Medical Research – uses NBCS during the production stage, which is extracted from the blood of slaughtered calves under 20 days old.

“The calves used in the extraction of this serum are taken away from their mothers shortly after birth, which traumatises and distresses both the mother and calf,” says PETA India Science Policy Adviser Dr Ankita Pandey. “PETA India looks to the Drugs Controller to ensure that vaccine manufacturers switch to available animal-free media that overcome the limitations associated with the use of animal-derived serum.”

The Prevention of Cruelty to Animals (Slaughter House) Rules, 2001, prohibits the slaughter of pregnant animals and animals under 3 months of age – therefore, the use of serum obtained by slaughtering a calf younger than 20 days of age for vaccine production should also not be allowed. Numerous states in India have banned the slaughter of cows and sometimes calves, bulls, and buffaloes. In a country where killing cows and often calves is prohibited by law, it would be considered inappropriate and unethical by most to import and use NBCS manufactured by killing those same animals in other countries.

The use of animal-derived components such as NBCS in vaccine production compromises the quality and reproducibility of research and is often associated with the risk of contamination by non-human proteins and pathogens. The use of animal-derived serum could also delay COVID-19 vaccine production if shortages are experienced as vaccine production increases – a concern avoided by the use of available, animal-free products.

Animal-free media are already commercially available and can be used to grow Vero cells for virus production instead of using NBCS extracted by slaughtering calves. PETA India argues that modernising methods of vaccine production is an immediate necessity – particularly in a country like India, whose public has religious, cultural, and emotional connections with cows and calves and where harming them is a punishable offence.

PETA India and its affiliate scientists have been leading efforts to end the use of animals for the production of serum. PETA Science Consortium International e.V., of which PETA India is a member, has online resources that researchers can use to replace foetal bovine serum and NBCS in cell culture media.

PETA India – whose motto reads, in part, that “animals are not ours to experiment on” – opposes speciesism, a human-supremacist worldview. For more information, please visit or follow the group on Twitter, Facebook, or Instagram.

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