Thymulin Peptide and Follicle Interaction
Thymulin is a naturally occurring peptide that has been suggested to stimulate hair follicle development and growth. Research on it has been restricted since it is a relatively young peptide. In this article we will renumerate on the body of research available for this burgeoning peptide.
Thymulin Peptide: What is it?
Zinc (Zn) and Thymulin are the two components that make up the metallopeptide known as Zinc-Thymulin. Zn is a trace mineral, and Thymulin is a well-defined nonapeptide hormone generated by thymic epithelial cells.
The antigenicity and biological activity of Thymulin are both dependent on the element zinc; hence, Thymulin is conjugated with zinc to create Zn-Thymulin.
Thymulin Peptide: Mechanism of Action
The hormone Thymulin, which is extracted from the thymus gland, has been hypothesized to primarily serve two roles, as suggested by the research that has been done so far on the subject.
Studies suggest it is an immunomodulatory molecule because it is purported to stimulate the differentiation of T cells inside and outside the thymus. It is considered highly effective on suppressor T-cells, which are the most vulnerable to its effects.
Second, research suggests that Thymulin may lengthen the anagen phase of the hair follicle, which is the period during which active growth occurs. The anagen phase of the hair cycle tends to become shorter with age. As a consequence of this, hair follicles become dormant and are unable to produce new hair. Particularly, Thymulin is proposed to be responsible for preventing this from occurring.
It is essential to understand that even if the process by which Thymulin may potentially stimulate hair growth is not too complicated, this process may not produce any results without zinc. Thymulin and zinc are mixed in an equal molecular ratio to ensure this peptide functions most effectively.
As suggested by the findings of several studies, a single zinc shortage was sufficient to prevent the development of T cells. This suggests that Thymulin could not perform its function without the mineral zinc, which is why it is used in conjugation as Zn-Thymulin.
Thymulin Peptide Properties
Findings imply that Thymulin may control hair development by stimulating the proliferation of hair follicles. It is speculated to be effective in the context of hair loss, particularly in instances of advanced age which may induce a natural decrease in anagen hair development periods. Additionally, it has been theorized to increase the natural coloring of the hair by encouraging melanogenesis.
Because of the influence that the peptide may potentially have on the development of T cells, it has been hypothesized to have the potential to be employed as an immunological modulator.
Thymulin Peptide Blends
Investigations purport that Thymulin is a peptide that may primarily focus on the management of hair follicle degeneration. As a result, it may be blended with other peptides employed in hair restoration techniques.
Peptides such as GHK-Cu, PTD-DBM, and Thymosin Beta 4 have been suggested to prevent hair loss and the growth of new hair follicles. These peptides are speculated to exert their potential via distinct methods; nonetheless, they may all contribute to these processes.
Thymulin vs. GHK-Cu
Peptides such as Thymulin and GHK-Cu have been proposed to aid in the context of hair loss and potentially enhance hair regeneration. On the one hand, they originate from various locations within an organism.
On the one hand, thymic epithelial cells are believed to be responsible for the production of Thymulin, while GHK-Cu may be detected in both saliva and urine.
Thymulin vs. PTD-DBM
Studies suggest that both of these peptides are used in the context of androgenetic alopecia; however, their origination points are distinct and are not interchangeable. The Thymulin created in the thymus is a naturally occurring peptide, while the PTD-DBM produced is a synthesized peptide.
Thymulin vs. Thymosin Beta 4
Research suggests that Thymulin and TB4 are naturally occurring peptides that may potentially contribute to the regeneration of hair follicles. It has been purported they accomplish this goal in quite different ways.
Researchers propose that Thymulin may directly affect the follicles, which causes them to remain in the anagen phase longer. On the other hand, TB4 is speculated to increase the proliferation of stem cells, which leads to the development of hair cells.
Scientists interested in further studying these compounds may find the highest quality peptides at corepeptides.com.
References
[i] Bach JF, Dardenne M. Thymulin, a zinc-dependent hormone. Med Oncol Tumor Pharmacother. 1989;6(1):25-9. doi: 10.1007/BF02985220. PMID: 2657247.
[ii] Pleau JM, Dardenne M, Bach JF. Modification de l’antigénicité du FTS (thymuline) par le zinc [Modification of the antigenicity of the serum thymic factor (thymulin) by zinc]. C R Seances Acad Sci III. 1981 May 11;292(17):991-3. French. PMID: 6791774.
[iii] Dardenne M, Pleau JM. Interactions between zinc and thymulin. Met Based Drugs. 1994;1(2-3):233-9. doi: 10.1155/MBD.1994.233. PMID: 18476235; PMCID: PMC2364880.
[iv] Famenini S, Goh C. Evidence for supplemental treatments in androgenetic alopecia. J Drugs Dermatol. 2014 Jul;13(7):809-12. PMID: 25007363.
Cover Photo by Hassaan Here on Unsplash
